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Flu Vaccination

The best way to protect against the flu is to get vaccinated each fall. To manufacture the vaccine, influenza viruses are grown in chicken eggs, harvested, and then killed through chemical means. The vaccine is then purified and tested for purity, safety, and its ability to stimulate protective antibody in humans.

The strains which are chosen to be included in the vaccine are those which scientists have determined to be the predominant strains during the current influenza season.

There are two types of vaccines:

  • The "flu shot"- an inactivated vaccine (containing killed virus) that is given with a needle. The flu shot is approved for use in people older than 6 months, including healthy people and people with chronic medical conditions.
  • The nasal-spray flu vaccine- a vaccine made with live, weakened flu viruses that do not cause the flu (LAIV or "Live Attenuated Influenza Vaccine"). LAIV also called Flumist is approved for use in healthy people 5 years to 49 years of age who are not pregnant.

Each vaccine contains three influenza viruses-one A (H3N2) virus, one A (H1N1) virus, and one B virus. The viruses in the vaccine change each year based on international surveillance and scientists' estimations about the types and strains of viruses which will circulate in a given year.

About 2 weeks after vaccination, antibodies that provide protection against influenza virus infection develop in the body. October or November is the best time to get vaccinated, since Influenza is most active during winters.

The Advisory Committee on Immunization Practices recommends that all persons aged 50 years or older be vaccinated with influenza vaccine every year, unless there are strong reasons for not doing so. For example, you should not get vaccinated if you've:

  • An allergic reaction to chicken eggs (welts, tongue swelling, difficulty breathing, loss of blood pressure, etc.)
  • A previous serious reaction to an influenza shot

People who should get vaccinated each year are:

1) People at high risk for complications from the flu:

  • People 65 years and older; All children 6 to 23 months of age;
  • People who live in nursing homes and other long-term care facilities that house those with long-term illnesses;
  • Adults and children 6 months and older with chronic heart or lung conditions, including asthma;
  • Adults and children 6 months and older who require regular medical care or were in a hospital during the previous year because of a metabolic disease (like diabetes), chronic kidney disease, or weakened immune system (including immune system problems caused by medicines or by infection with human immunodeficiency virus [HIV/AIDS]);
  • Children 6 months to 18 years of age who are on long-term aspirin therapy. (Children given aspirin while they have influenza are at risk of Reye syndrome.);
  • Women who will be pregnant during the influenza season.

2) People 50 to 64 years of age. Because nearly one-third of people of 50 to 64 years of age in the United States have one or more medical conditions that place them at increased risk for serious flu complications therefore vaccination is recommended for all persons aged 50 - 64 years.

3) People who can transmit flu to others at high risk for complications. Any person in close contact with someone in a high-risk group should get vaccinated. This includes all health-care workers, household contacts and out-of-home caregivers of children 0 to 23 months of age, and close contacts of people 65 years and older.

Vaccine Side Effects

Different side effects can be associated with the flu shot and LAIV.

The flu shot: Some minor side effects that could occur are:

  • Soreness, redness, or swelling where the shot was given
  • Fever (low grade)
  • Aches

Almost all people who receive influenza vaccine have no serious problems from it. However, on rare occasions, flu vaccination can cause serious problems, such as severe allergic reactions.

LAIV: The viruses in the nasal-spray vaccine are weakened and do not cause severe symptoms often associated with influenza illness. In children, side effects from LAIV can include

  • runny nose
  • headache
  • vomiting
  • muscle aches
  • fever




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